SOX7

SOX7 is a gene that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein may play a role in heart development and specification of endothelial cells.

Function

SOX7 is a member of the SOX family of transcription factors, which are characterized by the presence of a high-mobility group (HMG) DNA-binding domain. The SOX family is divided into nine groups (A to J), and SOX7 belongs to the F group along with SOX17 and SOX18. These proteins play key roles in heart, vascular, and blood cell development.

Clinical significance

Mutations in the SOX7 gene have been associated with several diseases. For example, a decrease in SOX7 expression has been observed in patients with acute myeloid leukemia (AML), suggesting that this gene may act as a tumor suppressor in this context. Additionally, SOX7 has been implicated in the development of endometrial cancer and lung cancer.

Research

Research into the role of SOX7 in development and disease is ongoing. Current areas of interest include its potential role in stem cell differentiation and its interaction with other transcription factors such as Wnt and Notch.

See also

• SOX genes
• Transcription factor
• Endothelial cells