SRD5A1

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SRD5A1-human-tissue-expression-pmid24309898

SRD5A1 (Steroid 5 Alpha-Reductase 1) is an enzyme that in humans is encoded by the SRD5A1 gene. This enzyme is a member of the steroid 5 alpha-reductase family, which plays a crucial role in the metabolism of steroids.

Function

The primary function of SRD5A1 is to catalyze the conversion of testosterone into dihydrotestosterone (DHT), a more potent androgen. This conversion is essential for the normal development of male external genitalia and secondary sexual characteristics. SRD5A1 is also involved in the metabolism of other steroids, including progesterone and corticosteroids.

Expression

SRD5A1 is expressed in various tissues, including the liver, skin, and prostate. Its expression is regulated by hormonal signals, particularly by androgens and estrogens.

Clinical Significance

Mutations in the SRD5A1 gene can lead to disorders of sexual development and other conditions related to abnormal steroid metabolism. Inhibitors of SRD5A1, such as finasteride and dutasteride, are used in the treatment of conditions like benign prostatic hyperplasia and androgenic alopecia.

Related Enzymes

SRD5A1 is one of the two isoenzymes of steroid 5 alpha-reductase, the other being SRD5A2. While both enzymes perform similar functions, they have different tissue distributions and physiological roles.

See Also

• Steroid 5 alpha-reductase
• Testosterone
• Dihydrotestosterone
• Benign prostatic hyperplasia
• Androgenic alopecia
• Finasteride
• Dutasteride