SW-620

SW-620 is a human colorectal cancer cell line that is commonly used in biomedical research. It was first established in 1976 from a metastatic site (lymph node) in a 51-year-old Caucasian male with colorectal adenocarcinoma.

History

The SW-620 cell line was established by A. Leibovitz in the Scott and White Clinic, Temple, Texas, USA, hence the prefix 'SW'. The cell line was derived from a metastatic site in a patient with colorectal adenocarcinoma. The primary tumor (SW-480) and its metastasis (SW-620) were obtained from the same patient, providing a unique model to study the genetic changes associated with the progression of colorectal cancer.

Characteristics

SW-620 cells are epithelial in morphology and grow in a monolayer. They have a doubling time of approximately 22 hours. The cells express carcinoembryonic antigen (CEA) and cytokeratin, but do not produce mucin. They are resistant to TNF-alpha-induced apoptosis and have mutations in the p53 and KRAS genes.

Applications

Due to their genetic and phenotypic characteristics, SW-620 cells are widely used in research to study the biology and treatment of colorectal cancer. They are particularly useful for studying the mechanisms of metastasis and drug resistance.

See also

• SW-480
• Cell line
• Colorectal cancer
• Biomedical research

References

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