Bendroflumethiazide
(Redirected from Salures)
Bendroflumethiazide is a thiazide diuretic used in the management of hypertension and edema. It works by inhibiting sodium reabsorption in the distal convoluted tubules in the kidneys, promoting the excretion of sodium and water while conserving potassium. This mechanism helps in reducing blood pressure and the removal of excess fluid from the body.
Mechanism of Action[edit | edit source]
Bendroflumethiazide inhibits the sodium/chloride transporter in the distal convoluted tubule, leading to an increase in the excretion of sodium, chloride, and water. This diuretic effect decreases plasma volume, promoting the reduction of blood pressure and the resolution of edema. Additionally, it has a mild effect on reducing the excretion of potassium, which can help in preventing hypokalemia, a common side effect of diuretics.
Indications[edit | edit source]
Bendroflumethiazide is primarily indicated for the treatment of:
- Hypertension - as a monotherapy or in combination with other antihypertensive agents.
- Edema - associated with heart failure, chronic liver disease, and renal dysfunction.
Pharmacokinetics[edit | edit source]
After oral administration, bendroflumethiazide is absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2 to 4 hours. It is extensively bound to plasma proteins and is metabolized in the liver. The elimination half-life is approximately 3 to 6 hours, and it is excreted mainly by the kidneys.
Adverse Effects[edit | edit source]
Common adverse effects of bendroflumethiazide include:
- Hypokalemia - low potassium levels in the blood.
- Hyponatremia - low sodium levels in the blood.
- Hyperuricemia - elevated levels of uric acid, which can exacerbate or precipitate gout attacks.
- Hyperglycemia - elevated blood glucose levels.
- Dizziness and light-headedness, particularly at the start of therapy.
Less common but more serious adverse effects may include:
- Severe electrolyte imbalances.
- Allergic reactions, including rash and photosensitivity.
- Pancreatitis and cholecystitis.
Contraindications[edit | edit source]
Bendroflumethiazide is contraindicated in patients with:
- Severe renal impairment.
- Anuria - absence of urine production.
- Known hypersensitivity to sulfonamide-derived drugs, as thiazides are chemically related to sulfonamides.
Drug Interactions[edit | edit source]
Bendroflumethiazide can interact with several other medications, including:
- Lithium - may increase lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) - may reduce the antihypertensive effect of bendroflumethiazide.
- Digitalis - increased risk of digitalis toxicity due to hypokalemia.
- Antidiabetic drugs - may require adjustment of antidiabetic medication doses due to hyperglycemia.
Dosage and Administration[edit | edit source]
The dosage of bendroflumethiazide varies depending on the condition being treated and the patient's response to therapy. It is typically taken once daily, preferably in the morning to avoid nocturia. Dose adjustments may be necessary based on the patient's renal function and electrolyte levels.
Conclusion[edit | edit source]
Bendroflumethiazide is a valuable medication in the management of hypertension and edema. However, its use requires careful monitoring of electrolytes and renal function to avoid adverse effects. Patients should be educated about the potential side effects and the importance of regular follow-up appointments to ensure safe and effective treatment.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD