Tianeptine

Tianeptine is a tricyclic antidepressant (TCA) primarily used for the treatment of major depressive disorder. It has also been used to treat anxiety, asthma, and irritable bowel syndrome. Unlike most TCAs, Tianeptine does not appear to be associated with adverse cognitive effects and may actually improve cognitive function, making it a potential treatment for depression-related cognitive deficits.

Pharmacology

Tianeptine is a serotonin reuptake enhancer (SRE), which is the opposite action of the more common serotonin reuptake inhibitor (SRI) class of antidepressants. It enhances the reuptake of serotonin, reducing the amount of serotonin in the synaptic cleft. This is thought to result in an increase in synaptic plasticity, which may contribute to its antidepressant effects.

Clinical use

Tianeptine is used primarily in the treatment of major depressive disorder, though it has also been used off-label for a variety of other conditions. It is typically taken orally, in tablet form, with a usual dosage of 12.5 mg three times daily.

Side effects

Common side effects of Tianeptine include nausea, constipation, abdominal pain, and headache. In rare cases, it can cause liver damage, and it has been associated with a risk of dependence and withdrawal symptoms.

History

Tianeptine was discovered and patented by the French society Laboratoires Servier in the 1960s. It was first marketed in France in 1989 under the brand name Stablon.

See also

• Antidepressant
• Serotonin
• Major depressive disorder