Secretory leukocyte protease inhibitor

Secretory leukocyte protease inhibitor (SLPI) is a protein that in humans is encoded by the SLPI gene. It is an 11.7-kDa cysteine-rich cationic protein found in various secretory fluids, such as bronchial secretions and seminal fluid.

Function

SLPI has anti-inflammatory, anti-microbial, and anti-viral properties. It is a potent inhibitor of leukocyte elastase and has a weaker activity against cathepsin G, another serine protease from leukocytes. SLPI also plays a role in the regulation of inflammation and wound healing.

Clinical significance

SLPI has been implicated in a number of diseases. It is known to be overexpressed in certain types of cancer, including lung and breast cancer, and has been suggested as a potential biomarker for these diseases. In addition, it has been shown to play a role in the body's response to HIV infection, with higher levels of SLPI associated with slower disease progression.

Research

Research into SLPI has focused on its potential as a therapeutic target in diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis, where its anti-inflammatory and anti-microbial properties could be beneficial. In addition, its role in cancer and HIV infection makes it a potential target for new treatments for these diseases.

See also

• Protease inhibitor (biology)
• Leukocyte
• Inflammation

References

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