Selegiline hydrochloride

Selegiline hydrochloride - the hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (mao) inhibitor, selegiline has the greatest affinity for type b mao, found mainly in the brain. Selegiline is converted by mao b to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor fad (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by mao b, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re uptake of dopamine by the neuron and prolong dopamine activity.

Resources[edit source]

Latest articles - Selegiline hydrochloride

This medical article is a stub. You can help WikiMD by expanding it.

‎ Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Selegiline hydrochloride for any updates.

‎

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.