Sercloremine
Sercloremine (also known as CGP-4718A) is a monoamine oxidase inhibitor (MAOI) and antidepressant that was developed but never marketed. It is selective for monoamine oxidase B (MAO-B) over monoamine oxidase A (MAO-A).
Pharmacology[edit | edit source]
Sercloremine is a selective inhibitor of MAO-B, which means it preferentially inhibits this subtype of monoamine oxidase. MAO-B is responsible for the breakdown of dopamine in the brain, so inhibiting this enzyme can increase dopamine levels. This can have a variety of effects, including improving mood and reducing symptoms of Parkinson's disease.
Development and Marketing[edit | edit source]
Sercloremine was developed by the pharmaceutical company Ciba-Geigy, but it was never marketed. The reasons for this are not clear, but it may have been due to concerns about the safety and efficacy of MAOIs in general.
See Also[edit | edit source]
References[edit | edit source]
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