Sesquiterpenoids

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Sesquiterpenoids, also known as sesquiterpenes, are a class of terpenes that consist of three isoprene units and have the molecular formula C15H24. They can be found in various plants and some insects, where they serve as pheromones and defensive substances. Sesquiterpenoids are known for their diverse array of chemical structures and their roles in plant defense and communication.

Structure and Biosynthesis[edit | edit source]

Sesquiterpenoids are derived from the terpene precursor farnesyl pyrophosphate (FPP), which undergoes various cyclization and rearrangement reactions to form the different structures of sesquiterpenoids. The biosynthesis of sesquiterpenoids is primarily catalyzed by enzymes known as sesquiterpene synthases. These enzymes facilitate the formation of the diverse structures observed in sesquiterpenoids, ranging from linear to cyclic molecules.

Types and Examples[edit | edit source]

Sesquiterpenoids are categorized based on their structure. Some common types include:

  • Farnesene - a linear sesquiterpene that is found in apple skins and other fruits.
  • Bisabolol - a cyclic sesquiterpene known for its presence in chamomile and its use in cosmetics for its soothing properties.
  • Artemisinin - a highly oxygenated sesquiterpene lactone used as an antimalarial drug, derived from the plant Artemisia annua.
  • Cedrene - found in cedarwood oil, used in perfumery and as an insect repellent.

Functions[edit | edit source]

Sesquiterpenoids have a variety of ecological and physiological functions:

  • Defensive Compounds - Many plants produce sesquiterpenoids to deter herbivores and pathogens. For example, the sesquiterpenoid gossypol is produced by cotton plants as a defense against insects.
  • Pheromones - Some sesquiterpenoids act as pheromones in insects, playing a role in communication and mating behaviors.
  • Fragrances and Flavors - Due to their volatile nature and distinct odors, sesquiterpenoids are used in the fragrance and flavor industries.

Medical and Commercial Applications[edit | edit source]

Sesquiterpenoids have various applications in medicine and industry:

  • Pharmaceuticals - Compounds like artemisinin are crucial in treating diseases such as malaria.
  • Cosmetics - Sesquiterpenoids like bisabolol are used in skincare products for their soothing properties.
  • Agriculture - Some sesquiterpenoids are used as natural pesticides due to their insecticidal properties.

Research and Future Prospects[edit | edit source]

Research into sesquiterpenoids continues to reveal new potential applications, particularly in medicine and sustainable agriculture. Their complex chemistry also makes them a subject of interest in synthetic biology, where efforts are underway to engineer microbes to produce these compounds more efficiently.

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Contributors: Prab R. Tumpati, MD