Potassium citrate/potassium hydrogen carbonate

A compound used in medicine and food industry

CaptionSynonyms

Potassium citrate

Drug Information
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Identifiers IUPAC Name		Chemical Data C H N O Molecular Weight

Potassium citrate is a potassium salt of citric acid with the molecular formula K₃C₆H₅O₇. It is a white, crystalline powder that is highly soluble in water. Potassium citrate is commonly used in the medical field as a urinary alkalinizer and is also employed in the food industry as a buffering agent.

Medical Uses

Potassium citrate is primarily used to treat and prevent kidney stones, particularly those composed of calcium oxalate and uric acid. By increasing the urinary pH, it helps to reduce the formation of these stones. It is also used to treat hypokalemia, a condition characterized by low levels of potassium in the blood.

Mechanism of Action

Potassium citrate works by alkalinizing the urine, which helps to dissolve uric acid stones and prevent the formation of new stones. It also increases the urinary excretion of citrate, which binds to calcium and reduces the formation of calcium oxalate stones.

Dosage and Administration

Potassium citrate is typically administered orally in the form of tablets or a liquid solution. The dosage depends on the specific condition being treated and the patient's response to therapy. It is important to follow the prescribed dosage and not to exceed the recommended amount.

Side Effects

Common side effects of potassium citrate include gastrointestinal discomfort, such as nausea, vomiting, and diarrhea. In some cases, it may cause hyperkalemia, a condition characterized by elevated levels of potassium in the blood, which can be serious if not managed properly.

Interactions

Potassium citrate can interact with other medications, such as ACE inhibitors, potassium-sparing diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs), which can increase the risk of hyperkalemia. It is important to inform healthcare providers of all medications being taken to avoid potential interactions.

Potassium Hydrogen Carbonate

Potassium hydrogen carbonate, also known as potassium bicarbonate, is another potassium salt with the formula KHCO₃. It is used as a leavening agent in baking and as a buffering agent in various applications. In medicine, it is sometimes used as an antacid to treat acid indigestion and heartburn.

Also see

• Potassium
• Citric acid
• Kidney stones
• Hypokalemia
• Urinary alkalinizer