Sitagliptin/simvastatin

Sitagliptin/Simvastatin is a combination medication used in the treatment of Type 2 diabetes and hypercholesterolemia. It contains two active ingredients: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, and Simvastatin, a statin. This combination is used when diet and exercise alone does not adequately control blood sugar and cholesterol levels.

Mechanism of Action

Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This results in increased levels of incretin hormones, which help to regulate insulin levels after meals and decrease the amount of glucose produced by the liver.

Simvastatin, on the other hand, works by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver. This results in lower levels of low-density lipoprotein (LDL), or "bad" cholesterol, and increased levels of high-density lipoprotein (HDL), or "good" cholesterol.

Indications

Sitagliptin/Simvastatin is indicated for the treatment of adults with Type 2 diabetes who also have hypercholesterolemia or mixed dyslipidemia. It is used in conjunction with a diet and exercise program to improve glycemic control and lower cholesterol levels.

Side Effects

Common side effects of Sitagliptin/Simvastatin include upper respiratory tract infection, headache, and diarrhea. Serious side effects may include pancreatitis, severe joint pain, and a condition called rhabdomyolysis, which can lead to kidney failure.

Contraindications

Sitagliptin/Simvastatin is contraindicated in patients with known hypersensitivity to either sitagliptin or simvastatin, in patients with active liver disease, and in women who are pregnant or breastfeeding.

Drug Interactions

Sitagliptin/Simvastatin may interact with other medications, including other antidiabetic drugs, anticoagulants, and certain antibiotics and antifungals. It is important to inform your healthcare provider of all medications you are currently taking.

See Also

• Type 2 diabetes
• Hypercholesterolemia
• Sitagliptin
• Simvastatin