Risankizumab-rzaa
(Redirected from Skyrizi)
What is Risankizumab-rzaa?[edit | edit source]
Risankizumab-rzaa, an interleukin-23 antagonist, is a humanized immunoglobulin G1 (IgG1) monoclonal antibody. Risankizumab-rzaa is produced by recombinant DNA technology in Chinese hamster ovary cells and has an approximate molecular weight of 149 kDa.
What are the uses of this medicine?[edit | edit source]
It is indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
How does this medicine work?[edit | edit source]
- Risankizumab-rzaa is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that selectively binds to the p19 subunit of human interleukin 23 (IL-23) cytokine and inhibits its interaction with the IL-23 receptor. IL-23 is a naturally occurring cytokine that is involved in inflammatory and immune responses.
- Risankizumab-rzaa inhibits the release of pro-inflammatory cytokines and chemokines.
Who Should Not Use this medicine?[edit | edit source]
None.
What are the brand names and dosage forms of this medicine?[edit | edit source]
- Brand name: Skyrizi; NDC codes: 0074-1050-01, 0074-1050-70, 0074-2042-02, 0074-2042-71, 0074-2100-01, 0074-2100-70.
- SKYRIZI Pen
- Injection: 150 mg/mL as a colorless to yellow and clear to slightly opalescent solution in each single-dose prefilled pen.
- SKYRIZI Prefilled Syringe
- Injection: 150 mg/mL as a colorless to yellow and clear to slightly opalescent solution in each single-dose prefilled syringe.
- Injection: 75 mg/0.83 mL as a colorless to slightly yellow and clear to slightly opalescent solution in each single-dose prefilled syringe.
Is this medicine FDA approved?[edit | edit source]
It is approved by US FDA on April 23, 2019.
What are the active and inactive ingredients in Risankizumab-rzaa?[edit | edit source]
- Active ingredient:
- Risankizumab - 75mg in 0.83mL
- Inactive ingredients:
- Succinic Acid - 0.049mg in 0.83mL
- Sorbitol - 34mg in 0.83mL
- Polysorbate 20 - 0.17mg in 0.83mL
- Water
- Sodium Succinate Hexahydrate - 0.88mg in 0.83mL
How should this medicine be used?[edit | edit source]
- Use SKYRIZI exactly as your healthcare provider tells you to use it.
- If you miss your SKYRIZI dose, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. Call your healthcare provider if you are not sure what to do.
- If you inject more SKYRIZI than prescribed, call your healthcare provider right away.
What side effects can this medication cause?[edit | edit source]
- Upper respiratory infections
- Headache
- Feeling tired
- Injection site reactions
- Fungal skin infections
What to do in case of emergency/overdose?[edit | edit source]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
Limited available data with SKYRIZI use in pregnant women are insufficient to evaluate a drug associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcome.
Can this medicine be used in children?[edit | edit source]
The safety and efficacy of SKYRIZI in pediatric patients less than 18 years of age have not yet been established.
What should I know about storage and disposal of this medication?[edit | edit source]
- Store in a refrigerator at 2°C to 8°C (36°F to 46° F).
- Do not freeze.
- Do not shake.
- Keep prefilled pens and prefilled syringes in the original cartons to protect from light.
- Not made with natural rubber latex.
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