Small round blue cell tumor

Small round blue cell tumor (SRBCT) is a diverse group of neoplasms characterized by small, round, relatively undifferentiated cells. They are observed under the microscope and appear blue due to their high nuclear content and scant cytoplasm. SRBCTs are malignant and often aggressive, rapidly growing tumors.

Classification

SRBCTs are classified into several types based on their tissue of origin. These include:

• Neuroblastoma
• Ewing's sarcoma
• Rhabdomyosarcoma
• Wilms' tumor
• Non-Hodgkin lymphoma
• Retinoblastoma
• Medulloblastoma
• Desmoplastic small round cell tumor

Diagnosis

Diagnosis of SRBCTs is challenging due to their similar histological appearance. It often requires the use of immunohistochemical stains and molecular techniques such as FISH and PCR to identify specific chromosomal translocations.

Treatment

Treatment of SRBCTs typically involves a combination of surgery, radiation therapy, and chemotherapy. The choice of treatment depends on the type of SRBCT, its location, and the patient's overall health.

Prognosis

The prognosis of SRBCTs varies widely depending on the type of tumor, its location, and the patient's overall health. Some types of SRBCTs, such as Wilms' tumor and retinoblastoma, have relatively good prognoses with appropriate treatment, while others, such as Ewing's sarcoma and desmoplastic small round cell tumor, have poorer prognoses.

See also

• Cancer
• Oncology
• Pathology