Solute carrier organic anion transporter family member 1A2

Solute Carrier Organic Anion Transporter Family Member 1A2 (SLCO1A2) is a protein that in humans is encoded by the SLCO1A2 gene. This protein is a member of the organic anion transporter (OATP) family, which is responsible for the uptake and transport of various endogenous and exogenous compounds.

Function

The SLCO1A2 protein is an integral membrane protein that mediates the sodium-independent uptake of numerous endogenous compounds including bile acids, steroid conjugates, thyroid hormones, and eicosanoids. It is also involved in the removal of drug compounds such as statins, antiviral drugs, and antibiotics from the blood into the liver.

Clinical Significance

Mutations in the SLCO1A2 gene can lead to deficiencies in the SLCO1A2 protein, which can result in a variety of clinical conditions. For example, reduced function of this protein can lead to decreased drug clearance, potentially leading to drug toxicity. Conversely, increased function of this protein can lead to increased drug clearance, potentially leading to reduced drug efficacy.

Research

Research into the SLCO1A2 gene and its associated protein is ongoing, with studies investigating its role in drug metabolism, disease susceptibility, and potential as a therapeutic target.

File:SLCO1A2 gene location.png

Location of the SLCO1A2 gene on chromosome 12.

See Also

• Organic anion-transporting polypeptide
• Solute carrier family