Somatostatin receptor 3

Somatostatin receptor 3 (SSTR3) is a protein that in humans is encoded by the SSTR3 gene. It is one of the five G protein-coupled receptors for somatostatin, a hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors.

Structure

The SSTR3 gene is located on the short (p) arm of chromosome 22 at position 13.3. The protein encoded by this gene is a multi-pass membrane protein that functions as a receptor for somatostatin-14 and somatostatin-28. It is one of the five somatostatin receptors, which are members of the G protein-coupled receptor family.

Function

SSTR3 is involved in the inhibition of the release of insulin, glucagon and growth hormone. It also plays a role in cell proliferation, apoptosis, and neuronal activities. The receptor is available in many tissues including the brain, pancreas, and gastrointestinal tract.

Clinical significance

Mutations in the SSTR3 gene have been associated with diseases such as acromegaly, a disorder characterized by excessive growth due to the overproduction of growth hormone. In addition, SSTR3 has been implicated in the pathogenesis of neuroendocrine tumors.

See also

• Somatostatin receptor
• G protein-coupled receptor
• Somatostatin