Spitz naevus
Spitz Naevus[edit | edit source]
A Spitz naevus is a type of benign skin lesion that often resembles melanoma, a dangerous form of skin cancer. It is named after Sophie Spitz, who first described it in 1948. Spitz naevi are most commonly found in children and adolescents, but they can occur at any age.
Characteristics[edit | edit source]
Spitz naevi typically present as small, dome-shaped, pink or red papules. They are usually less than 1 cm in diameter. The surface of a Spitz naevus can be smooth or slightly scaly, and they are often firm to the touch.
Histology[edit | edit source]
Under the microscope, Spitz naevi are characterized by large spindle and epithelioid cells. These cells are often arranged in nests and can show a variety of patterns. The presence of Kamino bodies, which are eosinophilic globules, is a common histological feature.
Diagnosis[edit | edit source]
Diagnosing a Spitz naevus can be challenging due to its similarity to melanoma. A biopsy is often required to distinguish between the two. Dermoscopy, a non-invasive skin imaging technique, can also aid in the diagnosis by revealing specific patterns associated with Spitz naevi.
Treatment[edit | edit source]
Most Spitz naevi are benign and do not require treatment. However, if there is any doubt about the diagnosis, or if the lesion changes in appearance, surgical excision may be recommended to rule out melanoma.
Prognosis[edit | edit source]
The prognosis for individuals with a Spitz naevus is excellent, as these lesions are benign. However, regular monitoring is advised to ensure that no malignant transformation occurs.
Epidemiology[edit | edit source]
Spitz naevi are relatively rare, accounting for less than 1% of all skin biopsies. They are more common in fair-skinned individuals and have no significant gender predilection.
See Also[edit | edit source]
- Melanoma
- Dermoscopy
- Skin biopsy
- Spitz, S. (1948). "Melanomas of childhood." *American Journal of Pathology*, 24(3), 591-609.
- Barnhill, R. L., & Cerroni, L. (2014). "Spitz Nevus and Atypical Spitz Tumor." *Dermatopathology*, 1(1), 67-77.
NIH genetic and rare disease info[edit source]
Spitz naevus is a rare disease.
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