Sterol regulatory element-binding protein 1

Sterol regulatory element-binding protein 1 (SREBP-1) is a transcription factor that belongs to the sterol regulatory element-binding proteins (SREBPs) family. SREBP-1 is encoded by the SREBF1 gene in humans. It plays a crucial role in the regulation of lipid metabolism, particularly in the synthesis of fatty acids and cholesterol.

Structure

SREBP-1 is a membrane-bound protein that is initially synthesized as an inactive precursor. It is activated through proteolytic cleavage, which releases the mature form of the protein into the nucleus where it binds to specific DNA sequences known as sterol regulatory elements (SREs).

Function

SREBP-1 is primarily involved in the regulation of genes related to fatty acid synthesis. It binds to the sterol regulatory element, located in the promoter region of target genes, and activates their transcription. This process is crucial for maintaining lipid homeostasis in the body.

Role in Disease

Alterations in the function or expression of SREBP-1 have been associated with several diseases, including diabetes, obesity, and cardiovascular disease. For instance, overexpression of SREBP-1 can lead to increased fatty acid synthesis and accumulation of lipids in tissues, contributing to the development of obesity and insulin resistance.

Research

Research on SREBP-1 has provided valuable insights into the regulation of lipid metabolism and the pathogenesis of metabolic diseases. Current research is focused on understanding the precise mechanisms of SREBP-1 regulation and exploring potential therapeutic targets for the treatment of diseases associated with dysregulated lipid metabolism.

File:SREBP Pathway.jpg

SREBP Pathway. SREBP-1 is a key regulator of lipid metabolism.

See Also

• Sterol regulatory element-binding protein 2
• Lipid metabolism
• Transcription factor
• Gene expression