Sticky platelet syndrome

Sticky Platelet Syndrome
Specialty	Hematology
Complications	Thrombosis, Stroke, Miscarriage
Causes	Genetic, possibly acquired
Risk factors	Family history, surgery, pregnancy
Diagnostic method	Blood tests, aggregation studies
Differential diagnosis	Antiphospholipid syndrome, Von Willebrand disease
Treatment	Antiplatelet drugs, Anticoagulants
Medication	Aspirin, Clopidogrel
Frequency	Rare

Sticky Platelet Syndrome (SPS) is a rare genetic disorder characterized by an increased tendency of the platelets to clump together, leading to thrombosis and related complications such as stroke and miscarriage. It is considered a form of thrombophilia.

Symptoms and Complications

Patients with Sticky Platelet Syndrome may be asymptomatic until they experience a thrombotic event. These events can include deep vein thrombosis (DVT), pulmonary embolism, stroke, or recurrent miscarriages. The syndrome is particularly concerning because it can lead to severe and potentially life-threatening conditions without prior symptoms.

Causes

The exact cause of Sticky Platelet Syndrome is not fully understood, but it is believed to have a genetic component. Some cases have shown familial patterns, suggesting a hereditary predisposition. Additionally, certain environmental factors such as surgery or pregnancy may trigger the symptoms in susceptible individuals.

Diagnosis

Diagnosis of Sticky Platelet Syndrome involves blood tests that assess platelet function and aggregation. Specific tests include platelet aggregation studies using agents like adenosine diphosphate (ADP) and epinephrine. These tests help in determining the abnormal clumping characteristics of platelets seen in SPS.

Treatment

Treatment for Sticky Platelet Syndrome primarily involves the use of antiplatelet drugs such as aspirin and clopidogrel. In some cases, anticoagulants may also be prescribed to prevent thrombosis. The choice of medication and treatment regimen depends on the severity of the condition and the presence of other risk factors.

Prognosis

With appropriate treatment, individuals with Sticky Platelet Syndrome can manage their condition effectively. However, they must be monitored regularly for any signs of thrombotic complications.

See also

• Thrombophilia
• Platelet
• Thrombosis
• Anticoagulant
• Antiplatelet drug