Structure specific recognition protein 1

Structure Specific Recognition Protein 1 (SSRP1) is a protein that in humans is encoded by the SSRP1 gene. SSRP1 is a member of the FACT complex, which is a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as transcription.

Function

SSRP1 is a high mobility group (HMG) protein that facilitates transcription by promoting the alteration of nucleosome structure. The encoded protein has a DNA-binding domain with broad specificity and, functionally, is involved in transcriptional regulation.

Clinical significance

Alterations in the gene encoding SSRP1 have been associated with cancer. SSRP1 is overexpressed in several types of cancer, including breast cancer and lung cancer. It has been suggested that SSRP1 could be a potential therapeutic target in cancer treatment.

Interactions

SSRP1 has been shown to interact with SPT16, another component of the FACT complex. This interaction is crucial for the function of the FACT complex in transcription.

See also

• FACT complex
• Nucleosome
• Transcription (genetics)

External links

• SSRP1 at the National Center for Biotechnology Information