Succinate dehydrogenase complex subunit C

Succinate dehydrogenase complex subunit C (SDHC) is a protein that in humans is encoded by the SDHC gene. It is a crucial component of the succinate dehydrogenase (SDH) complex (also known as complex II), which is a key enzyme complex of the mitochondrial respiratory chain.

Structure

The SDHC gene is located on the 1st chromosome, with its specific location being 1q23.3. The gene contains 6 exons. SDHC encodes a 15.8 kDa protein that is composed of 169 amino acids; 15 peptides have been observed through mass spectrometry data.

Function

The SDHC protein is a membrane anchor subunit that binds the catalytic subunits (SDHA, SDHB) to the inner mitochondrial membrane. The SDH complex is involved in complex II of the electron transport chain, which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Clinical Significance

Mutations in the SDHC gene are associated with a rare form of cancer known as paraganglioma. Paragangliomas are usually benign and are found in the head, neck, and torso. However, if a mutation occurs in the SDHC gene, it can lead to the formation of malignant paragangliomas.

See Also

• Succinate dehydrogenase
• SDHA
• SDHB
• Paraganglioma