Paraganglioma

Paraganglioma is a rare type of neoplasm that originates from the paraganglia, a group of cells that are dispersed throughout the body and are derived from the neural crest. These cells are associated with the autonomic nervous system, which controls involuntary body functions such as heart rate and blood pressure.

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Classification

Paragangliomas can be classified based on their location in the body. They can occur in the head and neck, thorax, abdomen, and pelvis. The most common type is the carotid body tumor, which is located at the bifurcation of the carotid artery.

Signs and symptoms

The symptoms of paraganglioma depend on the location of the tumor. Head and neck paragangliomas often present with symptoms such as a neck mass, tinnitus, and cranial nerve deficits. Thoracic, abdominal, and pelvic paragangliomas can cause symptoms related to mass effect or catecholamine secretion, such as hypertension, palpitations, and sweating.

Diagnosis

The diagnosis of paraganglioma is often made with imaging studies, such as computed tomography (CT) or magnetic resonance imaging (MRI). Biopsy is generally not recommended due to the risk of bleeding and catecholamine release.

Treatment

The treatment of paraganglioma depends on the location and size of the tumor, as well as the patient's overall health. Treatment options include surgery, radiation therapy, and medication to control symptoms.

Prognosis

The prognosis of paraganglioma is generally good, but it can vary depending on the location and size of the tumor, as well as the patient's overall health.

See also

• Pheochromocytoma
• Neuroendocrine tumor
• Neuroblastoma

References

Paraganglioma Resources
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