Sular
- a dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump p glycoprotein which is overexpressed in some multi drug resistant tumors and may improve the efficacy of some antineoplastic agents. (nci04)
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Sular for any updates.
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