Sulfametomidine

Sulfametomidine

Sulfametomidine is a sulfonamide antibacterial agent used in the treatment of various bacterial infections. It belongs to the class of sulfonamides, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfametomidine is known for its broad-spectrum activity against a variety of Gram-positive and Gram-negative bacteria.

Mechanism of Action

Sulfametomidine works by inhibiting the bacterial enzyme dihydropteroate synthase, which is crucial for the synthesis of folic acid in bacteria. Folic acid is necessary for the production of nucleic acids and proteins, and its inhibition leads to the suppression of bacterial growth and replication.

Pharmacokinetics

After oral administration, sulfametomidine is well absorbed from the gastrointestinal tract. It is widely distributed throughout the body, including the central nervous system. The drug is metabolized in the liver and excreted primarily through the kidneys.

Clinical Uses

Sulfametomidine is used to treat a variety of bacterial infections, including:

• Urinary tract infections
• Respiratory tract infections
• Gastrointestinal infections
• Skin and soft tissue infections

Side Effects

Common side effects of sulfametomidine include:

• Nausea
• Vomiting
• Diarrhea
• Rash
• Photosensitivity

Serious side effects, although rare, may include:

• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Agranulocytosis
• Aplastic anemia

Contraindications

Sulfametomidine is contraindicated in patients with:

• Hypersensitivity to sulfonamides
• Severe liver or kidney disease
• Pregnancy and breastfeeding

Related Pages

• Sulfonamide
• Antibacterial
• Dihydropteroate synthase
• Folic acid
• Gram-positive bacteria
• Gram-negative bacteria

External Links

-