Sulfametomidine
Sulfametomidine is a sulfonamide antibacterial agent used in the treatment of various bacterial infections. It belongs to the class of sulfonamides, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfametomidine is known for its broad-spectrum activity against a variety of Gram-positive and Gram-negative bacteria.
Mechanism of Action[edit | edit source]
Sulfametomidine works by inhibiting the bacterial enzyme dihydropteroate synthase, which is crucial for the synthesis of folic acid in bacteria. Folic acid is necessary for the production of nucleic acids and proteins, and its inhibition leads to the suppression of bacterial growth and replication.
Pharmacokinetics[edit | edit source]
After oral administration, sulfametomidine is well absorbed from the gastrointestinal tract. It is widely distributed throughout the body, including the central nervous system. The drug is metabolized in the liver and excreted primarily through the kidneys.
Clinical Uses[edit | edit source]
Sulfametomidine is used to treat a variety of bacterial infections, including:
- Urinary tract infections
- Respiratory tract infections
- Gastrointestinal infections
- Skin and soft tissue infections
Side Effects[edit | edit source]
Common side effects of sulfametomidine include:
Serious side effects, although rare, may include:
Contraindications[edit | edit source]
Sulfametomidine is contraindicated in patients with:
- Hypersensitivity to sulfonamides
- Severe liver or kidney disease
- Pregnancy and breastfeeding
Related Pages[edit | edit source]
- Sulfonamide
- Antibacterial
- Dihydropteroate synthase
- Folic acid
- Gram-positive bacteria
- Gram-negative bacteria
References[edit | edit source]
External Links[edit | edit source]
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