T(14;18)

T(14;18) is a chromosomal translocation commonly associated with certain types of cancer, specifically non-Hodgkin lymphoma (NHL). This translocation involves the movement of genetic material between chromosome 14 and chromosome 18, hence the name T(14;18).

Overview[edit | edit source]

The T(14;18) translocation is a genetic abnormality that results in the overexpression of the BCL2 gene. This gene is responsible for producing a protein that inhibits apoptosis, or programmed cell death. In normal cells, apoptosis is a crucial process that helps maintain the balance of cell growth and death. However, in cells with the T(14;18) translocation, the overexpression of BCL2 can lead to the survival of abnormal cells, which can then multiply and form a tumor.

Occurrence[edit | edit source]

T(14;18) is the most common chromosomal translocation in human lymphoma, occurring in 60-85% of follicular lymphomas and 20-30% of diffuse large B-cell lymphomas. It is also found in a small percentage of healthy individuals, suggesting that additional genetic or environmental factors may be necessary for lymphoma development.

Detection[edit | edit source]

The detection of T(14;18) can be achieved through various methods, including fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), and next-generation sequencing (NGS). These techniques can identify the presence of the translocation and help guide treatment decisions.

Treatment and Prognosis[edit | edit source]

The presence of T(14;18) can influence the treatment and prognosis of lymphoma. Patients with this translocation often have a more aggressive disease course and may require more intensive treatment. However, the impact of T(14;18) on survival is still a subject of ongoing research.

File:T(14;18) translocation.png

T(14;18) translocation in a lymphoma cell