TAAR5

TAAR5

TAAR5 (Trace Amine-Associated Receptor 5) is a G protein-coupled receptor (GPCR) that is part of the trace amine-associated receptor family. These receptors are known to be activated by trace amines, which are endogenous amines present in the nervous system at low concentrations.

Function

TAAR5 is primarily expressed in the olfactory epithelium and is involved in the detection of volatile amines, which are compounds that can be found in body odor and decomposing organic matter. This receptor plays a role in the olfactory system by contributing to the perception of certain smells.

Ligands

TAAR5 is activated by several ligands, including trimethylamine, a compound that is associated with the characteristic odor of rotting fish. This receptor's ability to detect trimethylamine suggests a role in social communication and behavioral responses to environmental cues.

Clinical Significance

Research into TAAR5 and other trace amine-associated receptors is ongoing, with potential implications for understanding neurological disorders and psychiatric conditions. The study of TAAR5 may provide insights into the mechanisms of olfactory dysfunction and its impact on human health.

See Also

• Trace amine-associated receptor
• G protein-coupled receptor
• Olfactory system

External Links

• TAAR5 on WikiMD

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