TAAR8

TAAR8 or Trace Amine-Associated Receptor 8 is a protein that in humans is encoded by the TAAR8 gene. TAAR8 belongs to a family of G protein-coupled receptors which are involved in sensing trace amines. Trace amines are a group of rare endogenous compounds that serve as neuromodulators in a number of mammalian brain structures.

Function

TAAR8 is a member of the TAAR family of receptors, also known as trace amine-associated receptors. These receptors are activated by trace amines, which are endogenous compounds present in very low levels in mammalian tissues. Trace amines are believed to play a significant role in regulating neurological and physiological processes.

Structure

Like other G protein-coupled receptors, TAAR8 is a seven-transmembrane protein. This means it spans the cell membrane seven times. The protein's structure allows it to receive signals from outside the cell and transmit them to the inside of the cell, initiating a cellular response.

Clinical Significance

Research into the function and potential clinical significance of TAAR8 is ongoing. Some studies suggest that alterations in trace amine-associated receptor function could be involved in mental and neurological disorders, such as schizophrenia, depression, and Parkinson's disease. However, more research is needed to fully understand the role of TAAR8 and other trace amine-associated receptors in human health and disease.

See Also

• Trace amine-associated receptor
• G protein-coupled receptor
• Neuromodulation