TFAP4

TFAP4 or Transcription Factor AP-4 is a protein that in humans is encoded by the TFAP4 gene. It is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors.

Function

TFAP4 is a transcription factor that binds to the E-box sequence CAGCTG. It plays a crucial role in the regulation of gene expression, cell proliferation, and differentiation. It is involved in various biological processes, including cell cycle regulation, apoptosis, and neural development.

Structure

The TFAP4 protein consists of a basic domain, a helix-loop-helix domain, and a leucine zipper domain. The basic domain is responsible for DNA binding, while the helix-loop-helix and leucine zipper domains are involved in protein dimerization.

Clinical Significance

Abnormal expression of TFAP4 has been associated with several types of cancer, including colorectal cancer, breast cancer, and lung cancer. It has been suggested as a potential therapeutic target for these cancers.

Research

Research is ongoing to understand the precise role of TFAP4 in cancer development and progression. Studies have shown that it may act as an oncogene, promoting tumor growth and metastasis.

See Also

• Transcription factor
• E-box
• Cell cycle
• Apoptosis
• Neural development