TGFβR3

Transforming growth factor beta receptor III (TGFβR3), also known as betaglycan, is a protein that in humans is encoded by the TGFBR3 gene. TGFβR3 is a transmembrane proteoglycan that binds to transforming growth factor beta (TGF-β) and is involved in the TGF-β signaling pathway.

Function

TGFβR3 acts as a co-receptor that enhances the binding of TGF-β to its type I and type II receptors. It plays a crucial role in modulating the cellular response to TGF-β, which is involved in various biological processes such as cell growth, differentiation, apoptosis, and extracellular matrix production.

Clinical significance

Alterations in the expression of TGFβR3 have been associated with several diseases, including cancer, fibrosis, and cardiovascular disease. In cancer, TGFβR3 can act as a tumor suppressor, and its loss or reduced expression is often observed in tumor progression.

Interactions

TGFβR3 interacts with various proteins and molecules in the TGF-β signaling pathway. It can bind to endoglin, another TGF-β co-receptor, and modulate the availability of TGF-β ligands to the signaling receptors.

See also

• Transforming growth factor beta
• TGF-β signaling pathway
• Receptor (biochemistry)

External links

• Template:GeneReviews
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