TGFβR3
TGFβR3 (Transforming Growth Factor Beta Receptor III) is a type of protein that in humans is encoded by the TGFBR3 gene. It is a member of the transforming growth factor beta (TGFβ) receptor family, a group of proteins that play crucial roles in cellular function and homeostasis.
Function[edit | edit source]
TGFβR3 is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. It has a large extracellular domain and a short cytoplasmic domain, with no apparent signaling motif. It binds to TGFβ ligands and presents them to the TGFβ type II receptor for signal transduction within the cell. TGFβR3 is thus considered a co-receptor rather than a primary receptor for TGFβ signaling.
Clinical significance[edit | edit source]
Alterations in the TGFBR3 gene or its expression have been implicated in several human diseases, including various types of cancer, Marfan syndrome, and Loeys-Dietz syndrome. In cancer, decreased expression of TGFBR3 is often associated with disease progression and poor prognosis.
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