TGM6
TGM6 or Transglutaminase 6 is a protein that in humans is encoded by the TGM6 gene. It is a member of the transglutaminase family, which are enzymes that catalyze the crosslinking of proteins by epsilon-([gamma]-glutamyl)lysine isopeptide bonds.
Function[edit | edit source]
TGM6 is predominantly expressed in the brain and may play a role in neurological disorders. It catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins, which could be relevant to the pathogenesis of certain neurological diseases.
Clinical significance[edit | edit source]
Mutations in the TGM6 gene have been associated with spinocerebellar ataxia type 35 (SCA35), a neurodegenerative disorder characterized by progressive motor dysfunction and loss of coordination.
Structure[edit | edit source]
The TGM6 protein is composed of 706 amino acids and has a molecular weight of approximately 79 kDa. It contains a transglutaminase core domain, which is responsible for its enzymatic activity.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
