TNFRSF1A
TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily Member 1A) is a protein that in humans is encoded by the TNFRSF1A gene. It is a member of the TNF-receptor superfamily. This receptor is capable of activating NF-kappaB, mediating apoptosis, and functioning as a regulator of inflammation. Antiapoptotic protein BCL2 has been shown to be a regulator of this receptor's signaling pathway.
Function[edit | edit source]
The protein encoded by the TNFRSF1A gene is a receptor for tumor necrosis factor (TNF). The receptor can activate NF-kappaB and mediate apoptosis. TNFRSF1A has been shown to interact with TRADD, TRAF2, and BCL2.
Clinical significance[edit | edit source]
Mutations in the TNFRSF1A gene are associated with TNF receptor associated periodic syndrome (TRAPS), and familial hibernian fever.
Interactions[edit | edit source]
TNFRSF1A has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TNFRSF1A at the US National Library of Medicine Medical Subject Headings (MeSH)
Template:TNF receptor superfamily
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