TNFRSF1A
TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily Member 1A) is a protein that in humans is encoded by the TNFRSF1A gene. It is a member of the TNF-receptor superfamily. This receptor is capable of activating NF-kappaB, mediating apoptosis, and functioning as a regulator of inflammation. Antiapoptotic protein BCL2 has been shown to be a regulator of this receptor's signaling pathway.
Function[edit | edit source]
The protein encoded by the TNFRSF1A gene is a receptor for tumor necrosis factor (TNF). The receptor can activate NF-kappaB and mediate apoptosis. TNFRSF1A has been shown to interact with TRADD, TRAF2, and BCL2.
Clinical significance[edit | edit source]
Mutations in the TNFRSF1A gene are associated with TNF receptor associated periodic syndrome (TRAPS), and familial hibernian fever.
Interactions[edit | edit source]
TNFRSF1A has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TNFRSF1A at the US National Library of Medicine Medical Subject Headings (MeSH)
| TNFRSF1A Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
