TNFSF18

TNFSF18 or Tumor Necrosis Factor Superfamily Member 18 is a protein that in humans is encoded by the TNFSF18 gene. It is also known as GITRL (Glucocorticoid-Induced TNFR-Related Ligand) and AITRL (Activation-Inducible TNF-Related Ligand).

Function

TNFSF18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for receptor TNFRSF18/AITR/GITR. It functions as an important regulator of immune responses, particularly within the T cell population. The interaction of this ligand with its receptor has been shown to trigger the NF-kappaB signaling pathway, which promotes cell proliferation.

Clinical Significance

Due to its role in immune regulation, TNFSF18 has been implicated in a variety of disease states. It has been associated with autoimmune diseases, cancer, and infectious diseases. In particular, its role in T cell regulation has made it a target for therapeutic interventions in diseases such as rheumatoid arthritis and cancer immunotherapy.

Interactions

TNFSF18 has been shown to interact with:

• TNFRSF18
• TNFRSF1A
• TNFRSF1B

See Also

• Tumor necrosis factor (TNF)
• TNFRSF18
• NF-kappaB