TNFSF18
TNFSF18 or Tumor Necrosis Factor Superfamily Member 18 is a protein that in humans is encoded by the TNFSF18 gene. It is also known as GITRL (Glucocorticoid-Induced TNFR-Related Ligand) and AITRL (Activation-Inducible TNF-Related Ligand).
Function[edit | edit source]
TNFSF18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for receptor TNFRSF18/AITR/GITR. It functions as an important regulator of immune responses, particularly within the T cell population. The interaction of this ligand with its receptor has been shown to trigger the NF-kappaB signaling pathway, which promotes cell proliferation.
Clinical Significance[edit | edit source]
Due to its role in immune regulation, TNFSF18 has been implicated in a variety of disease states. It has been associated with autoimmune diseases, cancer, and infectious diseases. In particular, its role in T cell regulation has made it a target for therapeutic interventions in diseases such as rheumatoid arthritis and cancer immunotherapy.
Interactions[edit | edit source]
TNFSF18 has been shown to interact with:
See Also[edit | edit source]
References[edit | edit source]
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