TRADD

TRADD is a protein that in humans is encoded by the TRADD gene. TRADD stands for TNFRSF1A-associated via death domain. It is a death domain-containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation.

Function

TRADD is a cell signaling adaptor protein that is involved in the TNF receptor pathway. It is a crucial component of the TNF-alpha signaling pathway and interacts with tumor necrosis factor receptor (TNFRSF1A/TNFR1) to mediate programmed cell death and NF-kappaB activation.

Clinical significance

Mutations in the TRADD gene have been associated with various diseases. For instance, it has been implicated in the pathogenesis of cancer, autoimmune diseases, and inflammatory diseases.

Interactions

TRADD has been shown to interact with:

• TNFRSF1A
• RIPK1
• TRAF2
• TRAF5
• FADD
• CASP8

See also

• TNF receptor
• TNF-alpha
• NF-kappaB

External links

• TRADD at the US National Library of Medicine Medical Subject Headings (MeSH)

TRADD Resources
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