TRADD
TRADD is a protein that in humans is encoded by the TRADD gene. TRADD stands for TNFRSF1A-associated via death domain. It is a death domain-containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation.
Function[edit | edit source]
TRADD is a cell signaling adaptor protein that is involved in the TNF receptor pathway. It is a crucial component of the TNF-alpha signaling pathway and interacts with tumor necrosis factor receptor (TNFRSF1A/TNFR1) to mediate programmed cell death and NF-kappaB activation.
Clinical significance[edit | edit source]
Mutations in the TRADD gene have been associated with various diseases. For instance, it has been implicated in the pathogenesis of cancer, autoimmune diseases, and inflammatory diseases.
Interactions[edit | edit source]
TRADD has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TRADD at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
