TRAF2

TRAF2 is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Function

TRAF2 and TRAF3 directly bind to the CD40 cytoplasmic domain and serve as mediators of the signal transduction. TRAF2 is essential for mediating downstream events such as JNK activation and CD40-induced B cell proliferation.

Interactions

TRAF2 has been shown to interact with:

• BIRC2,
• BIRC3,
• CHUK,
• CD40,
• CFLAR,
• FADD,
• IKBKG,
• MAP3K14,
• RIPK1,
• TNFRSF1A,
• TNFRSF1B,
• TNFRSF8,
• TNFRSF9,
• TNFRSF11A,
• TNFRSF13B,
• TNFRSF13C,
• TNFRSF14,
• TNFRSF17,
• TNFRSF25,
• TRAF1,
• TRAF3, and
• TRADD.

External links

• TRAF2 at GeneCards

TRAF2 Resources
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