BIRC3

BIRC3 (Baculoviral IAP Repeat Containing 3) is a protein that in humans is encoded by the BIRC3 gene. This protein belongs to a family of apoptosis inhibitors, which are known as IAPs (Inhibitors of Apoptosis Proteins).

Function

BIRC3 functions by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This interaction suppresses apoptosis and also plays a role in mediating antiviral responses.

Clinical Significance

Mutations in the BIRC3 gene have been associated with various types of cancer, including leukemia and lymphoma. In addition, BIRC3 has been implicated in the development of rheumatoid arthritis and other autoimmune diseases.

Structure

The BIRC3 protein is composed of three Baculoviral IAP repeat (BIR) domains and a C-terminal RING finger domain. The BIR domains are responsible for the anti-apoptotic activity of the protein, while the RING finger domain has E3 ubiquitin-protein ligase activity.

Research

Research into BIRC3 is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target for cancer treatment.

File:BIRC3 protein structure.jpg

Structure of the BIRC3 protein.

See Also

• Apoptosis
• Cancer
• Gene
• Protein
• Tumor necrosis factor

References

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