TRIM33

TRIM33 (Tripartite Motif Containing 33), also known as TIF1γ (Transcription Intermediary Factor 1 Gamma), is a protein encoded by the TRIM33 gene in humans. This protein is a member of the tripartite motif family, which is characterized by the presence of three distinct zinc finger domains: a RING finger, a B-box type 1, and a B-box type 2, as well as a coiled-coil region.

Function

TRIM33 is involved in various cellular processes, including transcriptional regulation, DNA repair, and signal transduction. It acts as a transcriptional co-repressor and is known to interact with SMAD proteins, playing a role in the TGF-beta signaling pathway.

Clinical Significance

Mutations or dysregulation of TRIM33 have been implicated in several cancers, including breast cancer, pancreatic cancer, and leukemia. TRIM33 is thought to function as a tumor suppressor gene, and its loss of function can contribute to tumorigenesis.

Interactions

TRIM33 interacts with various proteins, including SMAD2, SMAD3, and SMAD4, which are involved in the TGF-beta signaling pathway. These interactions are crucial for its role in transcriptional regulation and cell cycle control.

Research

Ongoing research is focused on understanding the precise mechanisms by which TRIM33 regulates gene expression and its potential as a therapeutic target in cancer treatment. Studies are also exploring its role in immune response and inflammatory diseases.

See Also

• Tripartite motif family
• TGF-beta signaling pathway
• Tumor suppressor gene

External Links

• [TRIM33 Gene - GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=TRIM33)
• [TRIM33 Protein - UniProt](https://www.uniprot.org/uniprot/Q9UPN9)