TRIM33
TRIM33, also known as Tripartite Motif Containing 33, is a protein that in humans is encoded by the TRIM33 gene. It is a member of the TRIM family of proteins, characterized by the presence of a tripartite motif. This motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled coil region.
Function[edit | edit source]
TRIM33 is a transcriptional corepressor that interacts with transforming growth factor-beta (TGF-beta) receptors. It negatively regulates TGF-beta signaling by recruiting the polycomb repressive complex 2 (PRC2) to the TGF-beta responsive genes and repressing their transcription. TRIM33 also functions as a monoubiquitin ligase and promotes the monoubiquitination of TGF-beta receptors, leading to their degradation.
Clinical Significance[edit | edit source]
Alterations in the TRIM33 gene have been associated with various cancers, including leukemia, lung cancer, and breast cancer. It has been suggested that TRIM33 could serve as a potential therapeutic target in these cancers.
See Also[edit | edit source]
References[edit | edit source]
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