TRPC2

TRPC2 is a gene that encodes the protein Transient receptor potential cation channel subfamily C member 2 in humans. This protein is a member of the transient receptor potential (TRP) family of non-selective cation channels.

Function

The TRPC2 protein is a calcium-permeable cation channel that is activated by pheromones in the vomeronasal organ, a part of the olfactory system responsible for the detection of pheromones. This channel is also activated by changes in intracellular calcium levels and is thought to play a role in calcium homeostasis.

Structure

The TRPC2 protein is composed of six transmembrane domains, a pore-forming loop between the fifth and sixth domains, and cytoplasmic N- and C-termini. The N-terminus contains ankyrin repeats, which are thought to play a role in protein-protein interactions.

Clinical Significance

Mutations in the TRPC2 gene have been associated with a reduction in the function of the vomeronasal organ, which can lead to a decreased ability to detect pheromones. This can have implications for social and reproductive behaviors.

See Also

• Transient receptor potential channel
• Vomeronasal organ
• Calcium homeostasis