TRPC6
TRPC6[edit | edit source]
TRPC6 is a member of the transient receptor potential channel (TRPC) family, which are a group of ion channels located in the cell membrane. These channels are involved in various physiological processes, including the regulation of calcium influx into cells. TRPC6 is particularly important in the kidney, lung, and vascular system.
Structure[edit | edit source]
TRPC6 channels are composed of six transmembrane domains with a pore region between the fifth and sixth domains. The channel is activated by diacylglycerol (DAG) in a phospholipase C (PLC)-dependent manner, but it is independent of inositol trisphosphate (IP3). This distinguishes TRPC6 from other TRPC family members.
Function[edit | edit source]
TRPC6 plays a crucial role in the regulation of glomerular filtration rate in the kidney by modulating the contraction of podocytes. In the vascular system, TRPC6 is involved in the regulation of smooth muscle cell contraction and blood pressure.
Clinical Significance[edit | edit source]
Mutations in the TRPC6 gene have been associated with focal segmental glomerulosclerosis (FSGS), a disease that affects the kidney's filtering units. These mutations can lead to altered channel function, resulting in proteinuria and progressive kidney damage.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
