Tapinarof

What is Tapinarof?

• Tapinarof (vtama) is an aryl hydrocarbon receptor agonist used to treat plaque psoriasis.

Benvitimod

What are the uses of this medicine?

• Tapinarof (vtama) cream is a prescription medicine used on the skin (topical) to treat plaque psoriasis in adults.

How does this medicine work?

• Tapinarof is an aryl hydrocarbon receptor (AhR) agonist.
• The exact mechanisms by which vtama cream shows its therapeutic action in psoriasis patients are unknown.

Who Should Not Use this medicine ?

• This medicine have no usage limitations.

What drug interactions can this medicine cause?

• No formal drug interaction studies have been conducted.

Is this medicine FDA approved?

• Tapinarof was approved for medical use in the United States in May 2022.

How should this medicine be used?

Recommended dosage:

• Apply a thin layer of vtama cream to affected areas once daily.

Administration:

• Apply a thin layer of vtama cream only to your psoriasis skin lesions 1 time a day. Avoid applying vtama cream to unaffected areas of your skin.
• Wash your hands after applying vtama cream unless you are using it to treat your hands.
• If someone else applies vtama cream for you, they should wash their hands after application.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Cream, 1%
• Each gram of vtama cream contains 10 mg of tapinarof.

This medicine is available in fallowing brand namesː

• vtama

What side effects can this medication cause?

The most common side effects of this medicine include:

• red raised bumps around the hair pores (folliculitis)
• pain or swelling in the nose and throat (nasopharyngitis)
• skin rash or irritation including itching and redness, peeling, burning, or stinging
• headache
• itching
• flu

What special precautions should I follow?

• Apply vtama cream once daily to psoriasis skin lesions only and avoid unaffected areas of skin.
• Wash hands after application unless vtama cream is for treatment of the hands.
• Advise patients that vtama cream is for external use only.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• The available data on vtama cream use in pregnant women are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.

Can this medicine be used in children?

• Safety and efficacy of vtama cream have not been established in pediatric subjects with psoriasis under 18 years of age.

What are the active and inactive ingredients in this medicine?

• Active ingredient: tapinarof
• Inactive ingredients: benzoic acid, butylated hydroxytoluene, citric acid monohydrate, diethylene glycol monoethyl ether, edetate disodium, emulsifying wax, medium-chain triglycerides, polyoxyl 2 stearyl ether, polyoxyl 20 stearyl ether, polysorbate 80, propylene glycol, purified water, and sodium citrate dihydrate.

Who manufactures and distributes this medicine?

• Marketed by: Dermavant Sciences Inc., 3780 Kilroy Airport Way, Long Beach, CA

What should I know about storage and disposal of this medication?

• Store vtama cream at room temperature between 68°F to 77°F (20°C to 25°C).
• Do not freeze vtama cream.
• Protect vtama cream from exposure to excessive heat.
• Keep vtama cream and all medicines out of the reach of children.

• Dailymed label info on Tapinarof
• FDA Tapinarof