Taurochenodeoxycholic acid

Taurochenodeoxycholic acid

Taurochenodeoxycholic acid

Taurochenodeoxycholic acid is a bile acid derived from chenodeoxycholic acid and conjugated with taurine. It plays a crucial role in the digestion and absorption of fats in the small intestine. This bile acid is synthesized in the liver and stored in the gallbladder before being released into the small intestine during digestion.

Structure

Taurochenodeoxycholic acid has a molecular formula of C26H45NO6S and a molecular weight of 499.7 g/mol. It is a conjugated bile acid, meaning it is bound to the amino acid taurine. The chemical structure of taurochenodeoxycholic acid consists of a steroid nucleus with a hydroxyl group and a carboxylic acid group.

Function

As a bile acid, taurochenodeoxycholic acid aids in the emulsification and solubilization of dietary fats in the small intestine. It facilitates the absorption of lipids, fat-soluble vitamins, and cholesterol by forming micelles with these substances. Additionally, taurochenodeoxycholic acid plays a role in the regulation of cholesterol metabolism and excretion.

Clinical Significance

Abnormal levels of taurochenodeoxycholic acid in the body can be indicative of liver or gallbladder disorders. Elevated levels may be observed in conditions such as cholestasis, while decreased levels may be associated with impaired bile acid synthesis or absorption.