Tektin-1

Tektin-1 is a protein that in humans is encoded by the TEKT1 gene. Tektin-1 is a component of the microtubules, which are a part of the cytoskeleton of eukaryotic cells.

Function

Tektin-1 is a structural protein involved in the formation of cilia and flagella. It is a part of the axonemal complex, a set of proteins that form the core structure of cilia and flagella. Tektin-1 is essential for the proper functioning of these structures, which play a crucial role in cell movement and signal transduction.

Clinical significance

Mutations in the TEKT1 gene have been associated with primary ciliary dyskinesia, a rare genetic disorder characterized by chronic respiratory tract infections, abnormally positioned internal organs, and infertility.

Structure

The TEKT1 gene is located on the long (q) arm of chromosome 17 at position 25. The protein encoded by this gene is a member of the tektin family of proteins. Tektin proteins are thought to form a template for the periodic arrangement of tubulin dimers in the axoneme.

See also

• Tektin
• Microtubule
• Cytoskeleton
• Primary ciliary dyskinesia

References

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