Temoporfin

Temoporfin is a photosensitizer used in photodynamic therapy to treat certain types of cancer. It is marketed under the brand name Foscan.

Chemistry[edit]

Temoporfin is a chlorin based photosensitizer. Its chemical formula is C44H32N4Na4O8, and its molecular weight is 862.72 g/mol. It is a dark green powder that is soluble in water.

Mechanism of Action[edit]

Temoporfin is activated by light of a specific wavelength (652 nm). When activated, it produces a form of oxygen known as singlet oxygen. This singlet oxygen can damage cells and tissues, particularly cancer cells. The damage is caused by the oxidation of cellular components, leading to cell death.

Clinical Use[edit]

Temoporfin is used in the treatment of head and neck cancer. It is administered intravenously and then activated by light delivered to the tumor site. This light can be delivered through a fiber optic cable, allowing for targeted treatment of the tumor.

Side Effects[edit]

Common side effects of temoporfin include skin photosensitivity, which can last for several weeks after treatment. Other side effects can include nausea, vomiting, and pain at the injection site.

Research[edit]

Research is ongoing into the use of temoporfin in other types of cancer, including esophageal cancer and lung cancer. Early results are promising, but more research is needed to determine the full potential of this treatment.