Tenatoprazole

Tenatoprazole is a proton pump inhibitor (PPI) used in the treatment of gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD). It is a prodrug – in the body, it is converted to its active form. The active form of tenatoprazole is a sulfenamide.

Pharmacology

Tenatoprazole works by irreversibly blocking the enzyme H+/K+ ATPase in the stomach's parietal cells. This enzyme is also known as the proton pump and is necessary for the final step in the production of gastric acid. By inhibiting this enzyme, tenatoprazole prevents the production of gastric acid.

Clinical use

Tenatoprazole is used in the treatment of conditions where a reduction in gastric acid secretion is required, such as GERD and PUD. It is also used in the treatment of Zollinger-Ellison syndrome, a condition where the stomach produces too much acid.

Side effects

The most common side effects of tenatoprazole are diarrhea, nausea, vomiting, abdominal pain, flatulence, and headache. In rare cases, it can cause allergic reactions, hepatitis, jaundice, anemia, and other blood disorders.

See also

• Proton pump inhibitor
• Gastroesophageal reflux disease
• Peptic ulcer disease

Tenatoprazole Resources
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