Testis specific serine kinase 1b

Testis specific serine kinase 1b (Tssk1b) is a protein that in humans is encoded by the TSSK1B gene. This protein is a member of the serine/threonine kinase family and is specifically expressed in the testis.

Function

The Tssk1b protein is a serine/threonine kinase that is thought to function in the meiotic phase of spermatogenesis. It is a testis-specific kinase 1B that is related to several other proteins that are known to be involved in the regulation of cell growth and differentiation.

Structure

The TSSK1B gene is located on the short (p) arm of chromosome 19 at position 13.2. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase is found in the cytoplasm and is only expressed in testis tissue.

Clinical significance

Mutations in the TSSK1B gene have been associated with male infertility. Studies have shown that a decrease in TSSK1B activity can lead to a decrease in sperm motility, which can result in infertility.

Research

Research into the TSSK1B gene and its associated protein is ongoing, with a focus on understanding its role in spermatogenesis and its potential role in male infertility.

See also

• Serine/threonine-specific protein kinase
• Spermatogenesis
• Male infertility