Tetradecylthioacetic
Tetradecylthioacetic Acid (TTA) is a synthetic fatty acid known for its lipid-modifying effects. It is often used in research settings to study lipid metabolism and related diseases, such as obesity and diabetes.
Overview[edit | edit source]
TTA is a sulfur-substituted fatty acid that has been shown to have several effects on lipid metabolism. It is known to increase fatty acid oxidation, reduce lipogenesis, and increase insulin sensitivity. These effects make it a useful tool for studying lipid-related diseases and conditions.
Mechanism of Action[edit | edit source]
The exact mechanism of action of TTA is not fully understood. However, it is believed to work by activating peroxisome proliferator-activated receptors (PPARs), which are involved in the regulation of lipid metabolism. Activation of these receptors leads to increased fatty acid oxidation and decreased lipogenesis.
Uses in Research[edit | edit source]
Due to its effects on lipid metabolism, TTA is often used in research settings to study diseases and conditions related to lipid metabolism. These include obesity, diabetes, and cardiovascular disease. It has also been used to study the effects of lipid metabolism on other conditions, such as cancer and inflammation.
Safety and Side Effects[edit | edit source]
As a research tool, TTA is generally considered safe for use in laboratory settings. However, like all substances, it can have side effects if not used properly. These can include gastrointestinal upset, skin irritation, and allergic reactions. It is important to handle TTA with care and to follow all safety guidelines when using it.
See Also[edit | edit source]
- Fatty acid
- Lipid metabolism
- Peroxisome proliferator-activated receptors
- Obesity
- Diabetes
- Cardiovascular disease
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Contributors: Prab R. Tumpati, MD