Thiazepine

Thiazepine is a class of heterocyclic compounds that contain a seven-membered ring with five carbon atoms, one nitrogen atom, and one sulfur atom. The thiazepine ring can be found in various natural products and pharmaceutical drugs.

Structure and Nomenclature

The basic structure of a thiazepine consists of a seven-membered ring with five carbon atoms, one nitrogen atom, and one sulfur atom. The position of the nitrogen and sulfur atoms can vary, leading to several isomers. The systematic name for thiazepines is based on the Hantzsch-Widman nomenclature system.

Occurrence and Uses

Thiazepines are found in a variety of natural products and pharmaceutical drugs. For example, the drug diltiazem is a thiazepine derivative used to treat high blood pressure and angina. Other thiazepine-based drugs include clopenthixol and flupenthixol, which are used as antipsychotics.

Synthesis

Thiazepines can be synthesized through several methods, including the condensation reaction of a diamine with a dithiol. Other methods involve the cyclization of a thioamide or the reaction of a diazonium salt with a thiol.

See Also

• Heterocyclic compound
• Diltiazem
• Clopenthixol
• Flupenthixol

Thiazepine Resources
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