Thiazide
(Redirected from Thiazides)
Thiazide is a type of molecule that is often used in medicine as a diuretic and antihypertensive. It is a class of drugs that inhibit the actions of the sodium-chloride symporter in the distal convoluted tubule of the kidneys. This results in a decrease in sodium reabsorption, leading to increased urine production and decreased fluid in the blood vessels, which helps to lower blood pressure.
History[edit | edit source]
Thiazides were first introduced in the 1950s as a treatment for hypertension. They have since become a first-line treatment for hypertension and are also used to treat edema associated with heart failure, liver cirrhosis, and kidney disease.
Mechanism of action[edit | edit source]
Thiazides work by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the kidneys. This prevents the reabsorption of sodium and chloride ions, leading to increased urine production. The decrease in fluid in the blood vessels helps to lower blood pressure.
Side effects[edit | edit source]
Common side effects of thiazides include dehydration, hypokalemia, hyponatremia, and hypercalcemia. Less common side effects include gout, hyperglycemia, and hyperlipidemia.
Examples[edit | edit source]
Examples of thiazides include hydrochlorothiazide, chlorothiazide, and bendroflumethiazide.
See also[edit | edit source]
Thiazide Resources | ||
---|---|---|
|
|
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD