Tiludronic acid
Tiludronic acid (also known as tiludronate) is a type of bisphosphonate medication. It is primarily used in the treatment of Paget's disease of bone and hypercalcemia of malignancy.
Etymology[edit | edit source]
The name "tiludronic acid" is derived from its chemical structure, which includes a titanium atom (Ti), a ludwigite group (Lu), and a dronic acid group.
Pharmacology[edit | edit source]
Tiludronic acid works by inhibiting osteoclast activity, which reduces bone resorption and turnover. This helps to normalize the rate of bone turnover and reduce bone pain in conditions such as Paget's disease.
Clinical uses[edit | edit source]
Tiludronic acid is used in the treatment of Paget's disease, a condition characterized by abnormal bone remodeling. It is also used to treat hypercalcemia of malignancy, a condition where there is too much calcium in the blood due to cancer.
Side effects[edit | edit source]
Common side effects of tiludronic acid include nausea, vomiting, diarrhea, and abdominal pain. Rare but serious side effects can include osteonecrosis of the jaw and atypical femoral fracture.
Related terms[edit | edit source]
- Bisphosphonate: A class of drugs that includes tiludronic acid.
- Osteoclast: A type of bone cell that breaks down bone tissue, the activity of which is inhibited by tiludronic acid.
- Paget's disease: A condition characterized by abnormal bone remodeling, which can be treated with tiludronic acid.
- Hypercalcemia: A condition where there is too much calcium in the blood, which can be treated with tiludronic acid.
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Contributors: Prab R. Tumpati, MD
