Tolazoline hydrochloride
Tolazoline Hydrochloride is a vasodilator that is primarily used in the treatment of hypertension and other conditions that involve constricted blood vessels. It is a non-selective competitive antagonist of the alpha-adrenergic receptor.
Pharmacology[edit | edit source]
Tolazoline Hydrochloride works by blocking the alpha-adrenergic receptors, which are found on the smooth muscle cells of blood vessels. This causes the blood vessels to relax and dilate, thereby reducing blood pressure. It is a non-selective antagonist, meaning it blocks both alpha-1 and alpha-2 adrenergic receptors.
Clinical Uses[edit | edit source]
Tolazoline Hydrochloride is used in the treatment of various conditions that involve constricted blood vessels. These include hypertension, Raynaud's disease, and certain types of heart failure. It can also be used to reverse the effects of alpha-adrenergic agonists, which are drugs that constrict the blood vessels.
Side Effects[edit | edit source]
Like all medications, Tolazoline Hydrochloride can cause side effects. These may include headache, nausea, dizziness, and palpitations. In rare cases, it can cause severe hypotension (low blood pressure), which can be life-threatening.
Contraindications[edit | edit source]
Tolazoline Hydrochloride should not be used in patients with a history of hypersensitivity to the drug. It is also contraindicated in patients with severe coronary artery disease, as it can cause a rapid increase in heart rate and blood pressure.
See Also[edit | edit source]
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