Tolibut

Tolibut is a GABAergic drug that was developed in the Soviet Union in the 1960s. It is a derivative of gamma-aminobutyric acid (GABA), a neurotransmitter that plays a key role in the central nervous system's regulation of neuronal excitability. Tolibut has been used in the treatment of various neurological and psychiatric disorders, including anxiety, insomnia, and certain types of epilepsy.

History

Tolibut was first synthesized in the Soviet Union in the 1960s as part of a larger effort to develop new psychotropic drugs. It was one of several GABA derivatives developed during this period, along with phenibut and picamilon. These drugs were designed to enhance the effects of GABA in the brain, with the aim of treating a range of neurological and psychiatric disorders.

Pharmacology

Tolibut is a GABA analogue, meaning it is structurally similar to GABA and can mimic its effects in the body. It works by binding to GABA receptors in the brain, which inhibits neuronal activity and produces a calming effect. This makes it potentially useful in the treatment of conditions characterized by excessive neuronal activity, such as anxiety and epilepsy.

Clinical Use

Tolibut has been used in the treatment of a variety of conditions, including anxiety, insomnia, and certain types of epilepsy. It has also been used to alleviate symptoms of alcohol withdrawal, as it can help to reduce the anxiety and restlessness often associated with this process.

Side Effects

Like all drugs, Tolibut can have side effects. These can include drowsiness, dizziness, and nausea. In rare cases, it can also cause more serious side effects such as hepatotoxicity (liver damage) and neurotoxicity (nerve damage).

See Also

• GABAergic drugs
• Phenibut
• Picamilon