Toloxatone

Toloxatone is a monoamine oxidase inhibitor (MAOI) that is used in the treatment of depression. It was introduced in France in 1984 by Théramex, but was later withdrawn from the market due to cases of hepatitis.

Pharmacology

Toloxatone is a selective inhibitor of monoamine oxidase A (MAO-A), a type of enzyme that breaks down monoamines in the body. By inhibiting MAO-A, toloxatone increases the levels of certain monoamines, such as serotonin, norepinephrine, and dopamine, in the brain. These neurotransmitters are known to play a key role in mood regulation, and their increased availability is thought to alleviate the symptoms of depression.

Medical uses

Toloxatone is used in the treatment of depression. It is typically prescribed for patients who have not responded to other antidepressant treatments. However, due to its potential side effects, it is usually considered a second-line treatment.

Side effects

The most common side effects of toloxatone include nausea, dizziness, and insomnia. In rare cases, it can cause more serious side effects, such as hepatitis. Due to these potential risks, patients taking toloxatone are usually closely monitored by their healthcare provider.

History

Toloxatone was first introduced in France in 1984 by Théramex, a pharmaceutical company. However, it was later withdrawn from the market due to cases of hepatitis associated with its use.

See also

• List of antidepressants
• Monoamine oxidase inhibitor

Toloxatone Resources
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